I'm seeing about 45-55 fps at 6048x1080 with everything in video quality except vegetation set to high, vegetation set to very high, SSAO method = HDAO, and no MSAA. But, I will occasionally get brief, noticeable dips into the mid 30s. I can crank everything up to very high/ultra, but then I'm stuck firmly in the 30-40 fps range with occasional dips into the 20s.
That's on 2 7950s in crossfire with 12.11 beta 11 drivers and 12.11 CAP2.
The minimap/HUD seem properly placed for me, but I have noticed an Eyefinity bug when swimming. While underwater, it looks like the screen is supposed to be overlayed with a fullscreen darkening effect. But, the effect is off centered. It shows up as a dark rectangle with about 1/3 on the left screen and 2/3 on the center screen.
Screenshot showing HUD placement:
Screenshot showing underwater effect placement: