I will assume you know how to set a "preset" in CCC and use Windows 7.
What you want is easy, as Haldi indicated (and just to expand on that).
I have found it is easiest to setup in the following order -
1) In Windows 7, select Screen Resolution, decide which monitor you want to use solo and set it as your "main display", then select the other monitors and select "disconnect this display".
You must select "apply" between steps.
Once you have "disconnected" the other 2 monitors, save this as a "preset" (solo or single)
The disconnected monitors are still powered on, Windows 7 simply does not feed them a video signal.
2) Enable all monitors and select "extend desktop to this display" for the 2 monitors that are not your main display.
Then simply set a "preset" (extended) for your extended desktop (assuming like most of us you also use 3 monitors for actual work
3) Set up your eyefinity setup including bezel compensation, then set a "preset" (eyefinity) for your eyefinity setup
Switch between "presets" as you set them up to check your work, and if you screw it up simply delete that "preset" and do it over.
Just be aware that when switching between modes there may be some flashing and what appear to be mistakes or false starts (not really much, a couple seconds at most, it just seems long and disconcerting the first time
)
Once you have it right, you can switch between any of the 3 modes by either right-clicking on the CCC icon in the taskbar and invoking a preset, invoking a preset after opening CCC, or from a "hotkey" keyboard shortcut that you can create when setting up a "preset".
Upgrading the driver will preserve the "presets", but a clean install with driver removal will require you to setup the presets again.
I've been using this "preset" setup since I started using eyefinity several years ago and it works perfectly.
No fuss, no bother, just a couple of mouse or keyboard clicks