Just installed the Collector's Edition and wanted to share my efforts.
1) I had an unusual problem that when I launch the game it keeps minimizing and I am back to the desktop. Could not get the game to run (tried killing every task I could with Task Manager). Finally found a mod that launches the game in windowed mode, then goes full screen after a few seconds, works!
Fake Fullscreen Mode Windowed - Alt Tab Fix by BUDA20
http://www.nexusmods.com/newvegas/mods/41381/?
2) I run 3 27" Asus LCDs at 1920x1080 each - 5760x1080. Hear are my edits to the ini files so far:
a) Launch the game single screen first, set up your keyboard assignments, play enough to save a game and quit.
b) Edit all 3 of these files to have all of the same settings,
then set them to read only.Note: Manually add the fScopeScissorAmount=0 to the [Display] section.
[gameinstalldirectory]\Fallout_default.ini
[%USERNAME%\Documents\MyGames\FalloutNV]\Fallout.ini
[%USERNAME%\Documents\MyGames\FalloutNV]\FallPrefs.ini
[Display]
fScopeScissorAmount=0
fDefaultFOV=110.0000
fPipboy1stPersonFOV=60.0
bEnableEyefinity=0
iSize W=5760
iSize H=1080
[Interface]
iSafeZoneX=870
iSafeZoneY=870
[RenderedTerminal]
fRenderedTerminalFOV=0.20
fRenderedTerminalZoom=40
[Fonts]
sFontFile_2=Textures\Fonts\Glow_Monofonto_VL_dialogs.fnt
sFontFile_5=Textures\Fonts\Glow_Monofonto_VL_dialogs.fnt
Remember to set the files to read only and back them up somewhere. Experiment with the values for your screen resolution, but the above should get you close to up and running.
3) To make the PipBoy easier to read, I also installed the no scanlines mod:
No scanlines or distort on PipBoy
http://www.nexusmods.com/newvegas/mods/34949/?
Copy the textures folder to your [game install directory]\data folder ( so it will be [game install directory]\data\textures )
So far the game plays well. I do see some annoying pop-in and pop-out textures on the landscapes, and some textures are blurry here and there, will do some more research...been playing for hours and nowhere near getting to the Las Vegas strip yet, big game!