This has been happening for me since I first installed my 5870 back in January. It happens to many folks with ATI cards. I just expect it, now. Though come to think o fit, I haven't seen it since installing 10.10c a few days ago...
The closest thing to a fix is to turn on your mouse cursor trails. It seems to always work, but personally, I'd rather have a fudged cursor. But at least the click area is still at top-left...
Defies belief that this would be the only solution, Is it infeasible it might be a setting I can change or turn off? Is it a driver only problem or could it be the catalyst suite ? Perhaps if I load driver only it might be resolved?