What I did first: Straight swap from 5850 to R9 290
Install latest Catalyst software (update)
Can create presets but they don't save correctly
Random freezes.
I repeated this but used the Add/Remove program to uninstall the driver and reinstall but still the same problems.
(My) Solution:Install Driver uninstaller: http://www.guru3d.com/files-details/display-driver-uninstaller-download.html
Reboot into Safe Mode (press F8 before Windows splash screen)
Run the driver uninstaller - remove everything AMD related!
Reboot.
Configured my monitors ungrouped (3 separate monitors, extended desktop)
Added this as a Preset (I named it normal)
Reboot
Created and configured Eyefinity group
Added this as a Preset
Reboot.
So far it seems to be working well and Skyrim is looking real purdy