I hardly notice bezels in 5x1, but I think it's because I was previously running 3x2. I went from a 4x2(running 3x2 for eyefinity) down to a 5x1 setup mostly because FPS were impossible in that formation. Also switching back and forth from eyefinity to extended was laggy and just downright buggy when I was running 8 monitors. I like most of the FPS I've tried so far in 5x1. Farcry 2 made me almost nauseous however, but I'm not sure why...maybe my settings were not optimal. Also, I might not be a good example, because I've only played a few hours since I changed to 5x1. But, I will say I like 5x1 more for everyday use.
My only worry, is that now, my center monitor gets my primary focus in 3x1L. I don't know if I would be able to back up and focus on the center 3 primarily or not. Also, right now I have 3 25's, I would be stepping down to either 22's or 23's.
-Erik